Heliocles I in Wikipedia
The Greco-Bactrian Heliocles, circ. 145-130 BCE, relative (son or brother) and successor of Eucratides the Great, was probably the last Greek king who reigned over the Bactrian country. His reign was a troubled one. According to Roman historian Justin, Eucratides was murdered by his son and co-ruler, though Justin fails to name the perpetrator. The patricide might have led to instability, even civil war, which caused the Indian parts of the empire to be lost to Indo-Greek king Menander I.
From 130 BCE a nomadic people, the Yuezhi, started to invade Bactria from the north and we could assume that Heliocles was killed in battle during this invasion. Details from Chinese sources seem to indicate that the nomad invasion did not end civilisation in Bactria entirely. Hellenised cities continued to exist for some time, and the well-organised agricultural systems were not demolished.
Even if this was the end of the original Greco-Bactrian kingdom, the Greeks continued to rule in northwestern India to the end of the 1st century BCE, under the Indo-Greek Kingdom. It is unclear whether the dynasty of Eucratides was extinguished with the death of Heliocles I or if members of the family emigrated eastwards. Several later Indo-Greek king, including Heliocles II, struck coins which could be associated with the dynasty.